Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. Database of Single Nucleotide Polymorphisms (dbSNP)įull Name AKT serine/threonine kinase 1 provided by HGNC Primary source HGNC:HGNC:391 See related Ensembl:ENSG00000142208 MIM:164730 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as AKT PKB RAC PRKBA PKB-ALPHA RAC-ALPHA Summary This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma.Database of Genomic Structural Variation (dbVar).Online Mendelian Inheritance in Man (OMIM). Database of Genotypes and Phenotypes (dbGaP).Structure (Molecular Modeling Database).Conserved Domain Search Service (CD Search).BLAST (Basic Local Alignment Search Tool).
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